ID   HT-29-M6
AC   CVCL_G077
SY   HT-29 M6; HT29-M6; HT29-5M6; 5M6
DR   cancercelllines; CVCL_G077
DR   Wikidata; Q54896517
RX   PubMed=9579576;
RX   PubMed=17311291;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0320 ! HT-29
SX   Female
AG   44Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 05-10-23; Version: 20
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RX   PubMed=9579576; DOI=10.1002/(SICI)1097-0215(19980504)76:3<383::AID-IJC16>3.0.CO;2-C;
RA   Lesuffleur T., Violette S., Vasile-Pandrea I., Dussaulx E., Barbat A.,
RA   Muleris M., Zweibaum A.;
RT   "Resistance to high concentrations of methotrexate and 5-fluorouracil
RT   of differentiated HT-29 colon-cancer cells is restricted to cells of
RT   enterocytic phenotype.";
RL   Int. J. Cancer 76:383-392(1998).
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RX   PubMed=17311291; DOI=10.1002/jcp.20999;
RA   Mayo C., Lloreta J., Real F.X., Mayol X.;
RT   "In vitro differentiation of HT-29 M6 mucus-secreting colon cancer
RT   cells involves a trychostatin A and p27(KIP1)-inducible
RT   transcriptional program of gene expression.";
RL   J. Cell. Physiol. 212:42-50(2007).
//