ID   HCC60
AC   CVCL_G002
SY   HCC0060; Hamon Cancer Center 60
DR   EFO; EFO_0006418
DR   ArrayExpress; E-MTAB-2706
DR   BioSample; SAMN03473068
DR   cancercelllines; CVCL_G002
DR   Cosmic; 1113279
DR   EGA; EGAS00001000610
DR   PharmacoDB; HCC60_507_2019
DR   Wikidata; Q54881769
RX   PubMed=12429618;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a NCI-H23 derivative (PubMed=25877200). Originally thought to originate from a 26 year old female patient with an ovarian cystadenocarcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00533.
CC   Population: African American.
CC   HLA typing: A*80:01,80:01; B*50:01,50:01; C*06:02,06:02; DQB1*06:13,06:13; DRB1*13:01,03:17 (PubMed=26589293).
CC   Karyotypic information: Has lost chromosome Y (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 795; ATM; Simple; p.Gln1919Pro (c.5756A>C); ClinVar=VCV000580726; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Trp332Ter (c.996G>A); ClinVar=VCV000376339; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Met246Ile (c.738G>C); ClinVar=VCV001758655; Zygosity=Homozygous (from parent cell line).
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
ST   Source(s): PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 12
ST   D16S539: 11
ST   D18S51: 14
ST   D21S11: 30
ST   D3S1358: 15
ST   D5S818: 12,13
ST   D7S820: 9,10
ST   D8S1179: 15
ST   FGA: 24
ST   Penta D: 8
ST   Penta E: 7,17
ST   TH01: 6
ST   TPOX: 8,9
ST   vWA: 16,17
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1547 ! NCI-H23
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 05-10-23; Version: 24
//
RX   PubMed=12429618;
RA   Rathi A., Virmani A.K., Schorge J.O., Elias K.J., Maruyama R.,
RA   Minna J.D., Mok S.C., Girard L., Fishman D.A., Gazdar A.F.;
RT   "Methylation profiles of sporadic ovarian tumors and nonmalignant
RT   ovaries from high-risk women.";
RL   Clin. Cancer Res. 8:3324-3331(2002).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//