Cellosaurus cell line MOLT-4 clone 8 (CVCL

Cellosaurus MOLT-4 clone 8 (CVCL_F827)

Cell line name

MOLT-4 clone 8

Synonyms

Molt-4 Clone 8; Molt-4 clone no.8; MOLT 4 clone 8; Molt 4 clone 8; Molt4 clone 8; Molt4 Clone8; MOLT-4 cl. 8; MOLT-4 cl.8; MOLT-F8; M4Cl8; M4C18; MOLT4/8

Accession

CVCL_F827

Resource Identification Initiative

To cite this cell line use: MOLT-4 clone 8 (RRID:CVCL_F827)

Comments

Population: Caucasian.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.

Sequence variations

Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 11389; STK11; Simple; p.Gln214Ter (c.640C>T); ClinVar=VCV000428759; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Heterozygous (from parent cell line).

Disease

Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0013 (MOLT-4)
Children:

CVCL_WU92 (MOLT-4.CCR5)

CVCL_S545 (MOLT-4/CCR5)

Sex of cell

Male

Age at sampling

19Y