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Cellosaurus STF1-169 (CVCL_F744)

[Text version]
Cell line name STF1-169
Synonyms STF1.169
Accession CVCL_F744
Resource Identification Initiative To cite this cell line use: STF1-169 (RRID:CVCL_F744)
Comments Population: Moroccan.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; HGNC:44; TAP2; Simple; p.Arg273Ter (c.817C>T) (R253*); ClinVar=VCV000013727; Zygosity=Homozygous (from parent cell line).
Disease Bare lymphocyte syndrome type 1 (NCIt: C171267)
Immunodeficiency by defective expression of MHC class I (ORDO: Orphanet_34592)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A5NE (STF-1)
Sex of cell Male
Age at sampling 6Y
Category Transformed cell line
Publications

PubMed=17977821; DOI=10.1074/jbc.M708139200
Demirel O., Waibler Z., Kalinke U., Grunebach F., Appel S., Brossart P., Hasilik A., Tampe R., Abele R.
Identification of a lysosomal peptide transport system induced during dendritic cell development.
J. Biol. Chem. 282:37836-37843(2007)

PubMed=18802093; DOI=10.4049/jimmunol.181.7.4894
Verweij M.C., Koppers-Lalic D., Loch S., Klauschies F., de la Salle H., Quinten E., Lehner P.J., Mulder A., Knittler M.R., Tampe R., Koch J., Ressing M.E., Wiertz E.J.H.J.
The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex.
J. Immunol. 181:4894-4907(2008)

Cross-references
Anatomy/cell type resources BTO; BTO_0003755
Encyclopedic resources Wikidata; Q54970575
Entry history
Entry creation11-Feb-2013
Last entry update19-Dec-2024
Version number12