ID   TS/A
AC   CVCL_F736
SY   TSA
DR   BTO; BTO:0004282
DR   CLO; CLO_0009405
DR   CLDB; cl4545
DR   ChEMBL-Cells; CHEMBL3308478
DR   ChEMBL-Targets; CHEMBL615017
DR   Lonza; 103
DR   Millipore; SCC177
DR   PubChem_Cell_line; CVCL_F736
DR   Wikidata; Q50433109
RX   PubMed=3455746;
RX   PubMed=3875361;
RX   PubMed=6546207;
RX   PubMed=11263530;
RX   PubMed=15004469;
RX   PubMed=31783695;
WW   https://en.wikipedia.org/wiki/TS/A
WW   http://www.lollini.it/tsa.htm
CC   Characteristics: Metastatic. When injected subcutaneously into syngeneic BALB/c mice, give rise to local tumors rapidly disseminating to the lungs.
CC   Karyotypic information: Triploid karyotype (PubMed=15004469).
CC   Sequence variation: Mutation; MGI; MGI:98834; Trp53; Simple; p.Arg270His (c.809G>A); Zygosity=Unspecified (PubMed=11263530).
CC   Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
CC   Breed/subspecies: BALB/cAnNCrlBR.
ST   Source(s): Millipore
ST   Mouse STR 1-1: 15
ST   Mouse STR 1-2: 17
ST   Mouse STR 11-2: 17
ST   Mouse STR 12-1: 16
ST   Mouse STR 13-1: 15.2,16.2
ST   Mouse STR 15-3: 22.3
ST   Mouse STR 17-2: 17
ST   Mouse STR 18-3: 18,19
ST   Mouse STR 19-2: 13,15
ST   Mouse STR 2-1: 16
ST   Mouse STR 3-2: 14
ST   Mouse STR 4-2: 21.3
ST   Mouse STR 5-5: 14
ST   Mouse STR 6-4: 17
ST   Mouse STR 6-7: 12
ST   Mouse STR 7-1: 25.1
ST   Mouse STR 8-1: 13
ST   Mouse STR X-1: 24,25
DI   NCIt; C21678; Malignant neoplasms of the mouse mammary gland
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Female
AG   1Y8M
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 29-06-23; Version: 16
//
RX   PubMed=3455746; DOI=10.1093/jnci/76.1.87;
RA   Nanni P., De Giovanni C., Lollini P.-L., Nicoletti G., Prodi G.;
RT   "Clones with different metastatic capacity and variant selection
RT   during metastasis: a problematic relationship.";
RL   J. Natl. Cancer Inst. 76:87-93(1986).
//
RX   PubMed=3875361; DOI=10.1038/bjc.1985.180;
RA   Nicoletti G., Brambilla P., De Giovanni C., Lollini P.-L., Del Re B.,
RA   Marocchi A., Mocarelli P., Prodi G., Nanni P.;
RT   "Colony-stimulating activity from the new metastatic TS/A cell line
RT   and its high- and low-metastatic clonal derivatives.";
RL   Br. J. Cancer 52:215-222(1985).
//
RX   PubMed=6546207; DOI=10.1007/BF00121199;
RA   Nanni P., De Giovanni C., Lollini P.-L., Nicoletti G., Prodi G.;
RT   "TS/A: a new metastasizing cell line from a BALB/c spontaneous mammary
RT   adenocarcinoma.";
RL   Clin. Exp. Metastasis 1:373-380(1983).
//
RX   PubMed=11263530; DOI=10.1038/sj.cgt.7700279;
RA   Odin L., Favrot M.-C., Poujol D., Michot J.-P., Moingeon P., Tartaglia J.,
RA   Puisieux I.;
RT   "Canarypox virus expressing wild type p53 for gene therapy in murine
RT   tumors mutated in p53.";
RL   Cancer Gene Ther. 8:87-98(2001).
//
RX   PubMed=15004469; DOI=10.1159/000076294;
RA   Jentsch I., Geigl J., Klein C.A., Speicher M.R.;
RT   "Seven-fluorochrome mouse M-FISH for high-resolution analysis of
RT   interchromosomal rearrangements.";
RL   Cytogenet. Genome Res. 103:84-88(2003).
//
RX   PubMed=31783695; DOI=10.3390/cancers11121889;
RA   De Giovanni C., Nicoletti G., Landuzzi L., Palladini A., Lollini P.-L.,
RA   Nanni P.;
RT   "Bioprofiling TS/A murine mammary cancer for a functional precision
RT   experimental model.";
RL   Cancers (Basel) 11:1889.1-1889.20(2019).
//