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Cellosaurus NCR-EW2 (CVCL_F678)

[Text version]
Cell line name NCR-EW2
Accession CVCL_F678
Resource Identification Initiative To cite this cell line use: NCR-EW2 (RRID:CVCL_F678)
Comments Population: Japanese.
Doubling time: 34.3 hours (PubMed=1764362).
Derived from site: In situ; Pelvis; UBERON=UBERON_0002355.
Sequence variations
  • Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 2 fusion (Ex7/Ex5) (PubMed=9738976).
Disease Extraskeletal Ewing sarcoma (NCIt: C7135)
Extraskeletal Ewing sarcoma (ORDO: Orphanet_370334)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 13Y
Category Cancer cell line
Publications

PubMed=1764362; DOI=10.1038/bjc.1991.458; PMCID=PMC1977836
Hara S., Adachi Y., Kaneko Y., Fujimoto J.-i., Hata J.-i.
Evidence for heterogeneous groups of neuronal differentiation of Ewing's sarcoma.
Br. J. Cancer 64:1025-1030(1991)

PubMed=9738976; DOI=10.1111/j.1349-7006.1998.tb03274.x; PMCID=PMC5921883
Urano F., Umezawa A., Yabe H., Hong W., Yoshida K., Fujinaga K., Hata J.-i.
Molecular analysis of Ewing's sarcoma: another fusion gene, EWS-E1AF, available for diagnosis.
Jpn. J. Cancer Res. 89:703-711(1998)

PubMed=12054564; DOI=10.1016/S0006-291X(02)00129-8
Yabe H., Fukuma M., Urano F., Yoshida K., Kato S., Toyama Y., Hata J.-i., Umezawa A.
Lack of matrix metalloproteinase (MMP)-1 and -3 expression in Ewing sarcoma may be due to loss of accessibility of the MMP regulatory element to the specific fusion protein in vivo.
Biochem. Biophys. Res. Commun. 293:61-71(2002)

Cross-references
Anatomy/cell type resources BTO; BTO_0004872
Encyclopedic resources Wikidata; Q54908248
Polymorphism and mutation databases Cosmic; 1085900
Entry history
Entry creation11-Feb-2013
Last entry update19-Dec-2024
Version number18