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Cellosaurus A2780/C200 (CVCL_F638)

[Text version]
Cell line name A2780/C200
Synonyms C200
Accession CVCL_F638
Resource Identification Initiative To cite this cell line use: A2780/C200 (RRID:CVCL_F638)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=1348364; DOI=10.1073/pnas.89.7.3070; PMCID=PMC48805
Godwin A.K., Meister A., O'Dwyer P.J., Huang C.-S., Hamilton T.C., Anderson M.E.
High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.
Proc. Natl. Acad. Sci. U.S.A. 89:3070-3074(1992)

PubMed=7954422
Johnson S.W., Swiggard P.A., Handel L.M., Brennan J.M., Godwin A.K., Ozols R.F., Hamilton T.C.
Relationship between platinum-DNA adduct formation and removal and cisplatin cytotoxicity in cisplatin-sensitive and -resistant human ovarian cancer cells.
Cancer Res. 54:5911-5916(1994)

Cross-references
Cell line databases/resources cancercelllines; CVCL_F638
Encyclopedic resources Wikidata; Q54606593
Gene expression databases GEO; GSM184394
GEO; GSM184395
Polymorphism and mutation databases Progenetix; CVCL_F638
Entry history
Entry creation11-Feb-2013
Last entry update19-Dec-2024
Version number17