| Cell line name |
2LMP |
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| Synonyms |
2-LMP |
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| Accession |
CVCL_EQ20 |
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| Resource Identification Initiative |
To cite this cell line use: 2LMP (RRID:CVCL_EQ20) |
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| Comments |
Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Breast adenocarcinoma (NCIt: C5214) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0062 (MDA-MB-231) |
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| Sex of cell |
Female |
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| Age at sampling |
51Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=9739048; DOI=10.1172/JCI3492; PMCID=PMC509097
Zhai Y.-F., Guo R.-B., Hsu T.-L., Yu G.-L., Ni J., Kwon B.S., Jiang G.-W., Lu J., Tan J., Ugustus M., Carter K., Rojas L., Zhu F., Lincoln C., Endress G., Xing L., Wang S., Oh K.-O., Gentz R., Ruben S.M., Lippman M.E., Hsieh S.-L., Yang D.-J.
LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer.
J. Clin. Invest. 102:1142-1151(1998) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_EQ20
|
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| Encyclopedic resources |
Wikidata; Q54584606
|
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| Gene expression databases |
GEO; GSM1401670
|
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| Entry history |
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| Entry creation | 26-Sep-2016 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 17 |
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