ID   CCRF-CEM C7H2-2C8
AC   CVCL_EP76
SY   CCRF-CEM-C7H2-2C8; CEM-C7H2-2C8; C7H2-2C8; CEMC7H2pEFrtTA-2C8
DR   cancercelllines; CVCL_EP76
DR   Wikidata; Q54809020
RX   PubMed=10467407;
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_EP75 ! CCRF-CEM C7H2
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 19-12-24; Version: 17
//
RX   PubMed=10467407; DOI=10.1038/sj.onc.1202820;
RA   Loffler M., Ausserlechner M.J., Tonko M., Hartmann B.L., Bernhard D.,
RA   Geley S., Helmberg A., Kofler R.;
RT   "c-Myc does not prevent glucocorticoid-induced apoptosis of human
RT   leukemic lymphoblasts.";
RL   Oncogene 18:4626-4631(1999).
//