Cell line name |
CCRF-CEM C7H2 |
Synonyms |
CCRF-CEM-C7H2; CEM-C7H2; CEM-C7.H2; CEM-C7-H2; CEMC7H2; C7H2 |
Accession |
CVCL_EP75 |
Resource Identification Initiative |
To cite this cell line use: CCRF-CEM C7H2 (RRID:CVCL_EP75) |
Comments |
Population: Caucasian. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_6825 (CCRF-CEM C7) Children:
|
Sex of cell |
Female |
Age at sampling |
3Y11M |
Category |
Cancer cell line |
STR profile |
Source(s): PubMed=15637111
Markers: Run an STR similarity search on this cell line |
Publications | PubMed=7812967 Strasser-Wozak E.M.C., Hattmannstorfer R., Hala M., Hartmann B.L., Fiegl M., Geley S., Kofler R. Splice site mutation in the glucocorticoid receptor gene causes resistance to glucocorticoid-induced apoptosis in a human acute leukemic cell line. Cancer Res. 55:348-353(1995) PubMed=8895760 Geley S., Hartmann B.L., Hala M., Strasser-Wozak E.M.C., Kapelari K., Kofler R. Resistance to glucocorticoid-induced apoptosis in human T-cell acute lymphoblastic leukemia CEM-C1 cells is due to insufficient glucocorticoid receptor expression. Cancer Res. 56:5033-5038(1996) PubMed=10467407; DOI=10.1038/sj.onc.1202820 Loffler M., Ausserlechner M.J., Tonko M., Hartmann B.L., Bernhard D., Geley S., Helmberg A., Kofler R. c-Myc does not prevent glucocorticoid-induced apoptosis of human leukemic lymphoblasts. Oncogene 18:4626-4631(1999) PubMed=15637111; DOI=10.1096/fj.04-3062fje Parson W., Kirchebner R., Muhlmann R., Renner K., Kofler A., Schmidt S., Kofler R. Cancer cell line identification by short tandem repeat profiling: power and limitations. FASEB J. 19:434-436(2005) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_EP75
|
Encyclopedic resources |
Wikidata; Q54809019
|
Gene expression databases |
GEO; GSM286229
GEO; GSM286230
GEO; GSM286231
GEO; GSM286232
GEO; GSM286233
GEO; GSM286234
GEO; GSM286235
GEO; GSM286236
GEO; GSM286237
GEO; GSM286238
GEO; GSM286239
GEO; GSM286240
|
Entry history |
Entry creation | 26-Sep-2016 |
Last entry update | 19-Dec-2024 |
Version number | 18 |
---|