ID   28SC-ES
AC   CVCL_EP74
SY   28SC-Endotoxin Sensitive
DR   cancercelllines; CVCL_EP74
DR   JCRB; JCRB1647
DR   Wikidata; Q54583799
RX   PubMed=12944673;
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. On the basis of the STR profile the parent cell line (SC) seems to be a U-937 derivative.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00526.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): JCRB
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 10,12
ST   D16S539: 12
ST   D5S818: 10,12
ST   D7S820: 9,11
ST   TH01: 6,9.3
ST   TPOX: 8,11
ST   vWA: 15
DI   NCIt; C8263; Adult acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6444 ! SC [Human contaminated U-937]
SX   Male
AG   37Y
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 05-10-23; Version: 16
//
RX   PubMed=12944673;
RA   Yamamoto A., Sakai T., Ochiai M., Kamachi K., Kataoka M.,
RA   Toyoizumi H., Horiuchi Y.;
RT   "A cell line assay system for predicting the response of human blood
RT   to endotoxin.";
RL   Jpn. J. Infect. Dis. 56:93-100(2003).
//