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Cellosaurus HCC827 ER4 (CVCL_EJ10)

[Text version]
Cell line name HCC827 ER4
Synonyms ER4
Accession CVCL_EJ10
Resource Identification Initiative To cite this cell line use: HCC827 ER4 (RRID:CVCL_EJ10)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_114785; Erlotinib.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=22751098; DOI=10.1038/ng.2330; PMCID=PMC3408577
Zhang Z.-F., Lee J.C., Lin L.-P., Olivas V., Au V., LaFramboise T., Abdel-Rahman M., Wang X.-Q., Levine A.D., Rho J.K., Choi Y.J., Choi C.-M., Kim S.-W., Jang S.J., Park Y.S., Kim W.S., Lee D.H., Lee J.-S., Miller V.A., Arcila M.E., Ladanyi M., Moonsamy P., Sawyers C.L., Boggon T.J., Ma P.C., Costa C., Taron M., Rosell R., Halmos B., Bivona T.G.
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer.
Nat. Genet. 44:852-860(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_EJ10
Encyclopedic resources Wikidata; Q54881786
Polymorphism and mutation databases Cosmic; 1716795
Entry history
Entry creation26-Sep-2016
Last entry update19-Dec-2024
Version number13