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Cellosaurus M229 R4 (CVCL_EI85)

[Text version]
Cell line name M229 R4
Accession CVCL_EI85
Resource Identification Initiative To cite this cell line use: M229 R4 (RRID:CVCL_EI85)
Comments Selected for resistance to: ChEBI; CHEBI_63637; Vemurafenib (Zelboraf; PLX4032).
Sequence variations
  • Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D748 (M229)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=21107323; DOI=10.1038/nature09626; PMCID=PMC3143360
Nazarian R., Shi H.-B., Wang Q., Kong X.-J., Koya R.C., Lee H., Chen Z.-G., Lee M.-K., Attar N., Sazegar H., Chodon T., Nelson S.F., McArthur G.A., Sosman J.A., Ribas A., Lo R.S.
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.
Nature 468:973-977(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_EI85
Encyclopedic resources Wikidata; Q54903536
Polymorphism and mutation databases Cosmic; 1545604
Entry history
Entry creation26-Sep-2016
Last entry update19-Dec-2024
Version number11