ID   DCR9
AC   CVCL_EI70
SY   DCR 9
DR   cancercelllines; CVCL_EI70
DR   ColonAtlas; DCR9
DR   Cosmic; 1690658
DR   Wikidata; Q54828680
RX   PubMed=22270724;
CC   Population: Caucasian.
CC   Selected for resistance to: DrugBank; DB00002; Cetuximab (Erbitux).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Ser492Arg (c.1476C>A); ClinVar=VCV000376341; Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=22270724).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C2955; Colorectal carcinoma
DI   NCIt; C6728; Gardner syndrome
DI   ORDO; Orphanet_79665; Gardner syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6895 ! DiFi
SX   Female
AG   46Y
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 05-10-23; Version: 13
//
RX   PubMed=22270724; DOI=10.1038/nm.2609;
RA   Montagut C., Dalmases A., Bellosillo B., Crespo M., Pairet S.,
RA   Iglesias M., Salido M., Gallen M., Marsters S., Tsai S.-P., Minoche A.,
RA   Seshagiri S., Serrano S., Himmelbauer H., Bellmunt J., Rovira A.,
RA   Settleman J., Bosch F., Albanell J.;
RT   "Identification of a mutation in the extracellular domain of the
RT   epidermal growth factor receptor conferring cetuximab resistance in
RT   colorectal cancer.";
RL   Nat. Med. 18:221-223(2012).
//