ID   C058
AC   CVCL_EI49
SY   C058M
DR   cancercelllines; CVCL_EI49
DR   Cosmic; 2465275
DR   GEO; GSM4178070
DR   Wikidata; Q54800064
RX   PubMed=22250051;
RX   PubMed=22383533;
RX   PubMed=23890154;
CC   Characteristics: Early passage culture.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Leu597Ser (c.1789_1790delCTinsTC); ClinVar=VCV000375942; Zygosity=Heterozygous (PubMed=22383533; PubMed=23890154).
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: Metastatic; Not specified.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   39Y
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 19-12-24; Version: 10
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RX   PubMed=22250051; DOI=10.1002/gcc.21932;
RA   Dutton-Regester K., Aoude L.G., Nancarrow D.J., Stark M.S.,
RA   O'Connor L., Lanagan C., Pupo G.M., Tembe V., Carter C.D.,
RA   O'Rourke M., Scolyer R.A., Mann G.J., Schmidt C.W., Herington A.,
RA   Hayward N.K.;
RT   "Identification of TFG (TRK-fused gene) as a putative metastatic
RT   melanoma tumor suppressor gene.";
RL   Genes Chromosomes Cancer 51:452-461(2012).
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RX   PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676;
RA   Dutton-Regester K., Irwin D., Hunt P., Aoude L.G., Tembe V.,
RA   Pupo G.M., Lanagan C., Carter C.D., O'Connor L., O'Rourke M.,
RA   Scolyer R.A., Mann G.J., Schmidt C.W., Herington A., Hayward N.K.;
RT   "A high-throughput panel for identifying clinically relevant mutation
RT   profiles in melanoma.";
RL   Mol. Cancer Ther. 11:888-897(2012).
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RX   PubMed=23890154; DOI=10.1111/pcmr.12153;
RA   Dutton-Regester K., Kakavand H., Aoude L.G., Stark M.S.,
RA   Gartside M.G., Johansson P., O'Connor L., Lanagan C., Tembe V.,
RA   Pupo G.M., Haydu L.E., Schmidt C.W., Mann G.J., Thompson J.F.,
RA   Scolyer R.A., Hayward N.K.;
RT   "Melanomas of unknown primary have a mutation profile consistent with
RT   cutaneous sun-exposed melanoma.";
RL   Pigment Cell Melanoma Res. 26:852-860(2013).
//