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Cellosaurus SKBR3-LAPRb (CVCL_EI08)

[Text version]
Cell line name SKBR3-LAPRb
Accession CVCL_EI08
Resource Identification Initiative To cite this cell line use: SKBR3-LAPRb (RRID:CVCL_EI08)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:49603; Lapatinib (Tykerb; Tyverb).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1748; CDH1; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0033 (SK-BR-3)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
Publications

PubMed=26883193; DOI=10.18632/oncotarget.7317; PMCID=PMC4905492
Creedon H., Gomez-Cuadrado L., Tarnauskaite Z., Balla J., Canel M., MacLeod K.G., Serrels B., Fraser C., Unciti-Broceta A., Tracey N., Le Bihan T., Klinowska T., Sims A.H., Byron A., Brunton V.G.
Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy.
Oncotarget 7:11539-11552(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_EI08
Encyclopedic resources Wikidata; Q54954671
Entry history
Entry creation13-Jul-2016
Last entry update05-Oct-2023
Version number11