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Cellosaurus MCF7-TamR (CVCL_EG55)

[Text version]
Cell line name MCF7-TamR
Accession CVCL_EG55
Resource Identification Initiative To cite this cell line use: MCF7-TamR (RRID:CVCL_EG55)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:41774; Tamoxifen.
Omics: Deep phosphoproteome analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=26330541; DOI=10.1074/mcp.M115.050484; PMCID=PMC4638033
Wu X.-Y., Zahari M.S., Renuse S., Nirujogi R.S., Kim M.-S., Manda S.S., Stearns V., Gabrielson E.W., Sukumar S., Pandey A.
Phosphoproteomic analysis identifies focal adhesion kinase 2 (FAK2) as a potential therapeutic target for tamoxifen resistance in breast cancer.
Mol. Cell. Proteomics 14:2887-2900(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_EG55
Encyclopedic resources Wikidata; Q54904464
Proteomic databases PRIDE; PXD001812
Entry history
Entry creation13-Jul-2016
Last entry update05-Oct-2023
Version number12