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Cellosaurus BroLi (CVCL_E997)

[Text version]
Cell line name BroLi
Accession CVCL_E997
Resource Identification Initiative To cite this cell line use: BroLi (RRID:CVCL_E997)
Comments Doubling time: 5 days (PubMed=20444890); 4-5 days (PubMed=30873613).
Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
Omics: Array-based CGH.
Omics: Deep quantitative proteome analysis.
Omics: SNP array analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Disease Merkel cell carcinoma (NCIt: C9231)
Cutaneous neuroendocrine carcinoma (ORDO: Orphanet_79140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): PubMed=30873613

Markers:
AmelogeninX,Y
CSF1PO10,12
D3S135817,18
D5S81810,11
D7S8209,11
D8S117911,17
D13S31710,12
D16S53912,13
D18S5116,19
D21S1127.2,29.2
FGA20,26
Penta D13
Penta E10
TH016,9
TPOX8,11
vWA17

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Publications

PubMed=20444890; DOI=10.1128/JVI.02400-09; PMCID=PMC2898224
Houben R., Shuda M., Weinkam R., Schrama D., Feng H.-C., Chang Y., Moore P.S., Becker J.C.
Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens.
J. Virol. 84:7064-7072(2010)

PubMed=22363598; DOI=10.1371/journal.pone.0031255; PMCID=PMC3281946
Hafner C., Houben R., Baeurle A., Ritter C., Schrama D., Landthaler M., Becker J.C.
Activation of the PI3K/AKT pathway in Merkel cell carcinoma.
PLoS ONE 7:E31255-E31255(2012)

PubMed=23563200; DOI=10.1038/jid.2013.169
Houben R., Dreher C., Angermeyer S., Borst A., Utikal J.S., Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

PubMed=27121059; DOI=10.18632/oncotarget.8793; PMCID=PMC5078066
Hesbacher S., Pfitzer L., Wiedorfer K., Angermeyer S., Borst A., Haferkamp S., Scholz C.-J., Wobser M., Schrama D., Houben R.
RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells.
Oncotarget 7:32956-32968(2016)

PubMed=30873613; DOI=10.1002/ijc.32280
Schrama D., Sarosi E.-M., Adam C., Ritter C., Kaemmerer U., Klopocki E., Konig E.-M., Utikal J.S., Becker J.C., Houben R.
Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: integration pattern suggest that large T antigen truncating events occur before or during integration.
Int. J. Cancer 145:1020-1032(2019)

PubMed=31889939; DOI=10.1186/s12014-019-9263-z; PMCID=PMC6921584
Kotowski U., Erovic B.M., Schnoll J., Stanek V., Janik S., Steurer M., Mitulovic G.
Quantitative proteome analysis of Merkel cell carcinoma cell lines using SILAC.
Clin. Proteomics 16:42.1-42.13(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_E997
Encyclopedic resources Wikidata; Q54798314
Gene expression databases GEO; GSM1904845
Polymorphism and mutation databases Cosmic; 1699818
Progenetix; CVCL_E997
Proteomic databases PRIDE; PXD008181
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number17