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Cellosaurus Hs 578T Hc5-2 (CVCL_E8BT)

[Text version]
Cell line name Hs 578T Hc5-2
Synonyms Hc5-2
Accession CVCL_E8BT
Resource Identification Initiative To cite this cell line use: Hs 578T Hc5-2 (RRID:CVCL_E8BT)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=MGI; MGI:98834; Trp53 (Note=With p.Glu168Gly and p.Met234Ile).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012612; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val157Phe (c.469G>T); ClinVar=VCV000012353; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0332 (Hs 578T)
Sex of cell Female
Age at sampling 74Y
Category Cancer cell line
Publications

PubMed=7949216; DOI=10.1007/BF00666061
Eliyahu D., Evans S., Rosen N., Eliyahu S., Zwiebel J.A., Paik S., Lippman M.E.
p53Val135 temperature sensitive mutant suppresses growth of human breast cancer cells.
Breast Cancer Res. Treat. 30:167-177(1994)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1