ID   Hs 578T Hc5-1
AC   CVCL_E8BS
SY   Hc5-1
RX   PubMed=7949216;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012612; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val157Phe (c.469G>T); ClinVar=VCV000012353; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=MGI; MGI:98834; Trp53 (Note=With p.Glu168Gly and p.Met234Ile).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: In situ; Breast; UBERON=UBERON_0000310.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0332 ! Hs 578T
SX   Female
AG   74Y
CA   Cancer cell line
DT   Created: 10-04-25; Last updated: 14-08-25; Version: 2
//
RX   PubMed=7949216; DOI=10.1007/BF00666061;
RA   Eliyahu, Daniel
RA   Evans, Steve
RA   Rosen, Neal
RA   Eliyahu, Siona
RA   Zwiebel, James A.
RA   Paik, Soonmyung
RA   Lippman, Marc E.
RT   "p53Val135 temperature sensitive mutant suppresses growth of human
RT   breast cancer cells.";
RL   Breast Cancer Res. Treat. 30:167-177(1994).
//