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Cellosaurus PLH (CVCL_E810)

[Text version]
Cell line name PLH
Accession CVCL_E810
Resource Identification Initiative To cite this cell line use: PLH (RRID:CVCL_E810)
Comments Part of: 10th International Histocompatibility Workshop (10IHW) cell line panel.
Population: Caucasian; Scandinavian.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: HLA class II peptidome analysis by proteomics.
Omics: MHC region genome.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
HLA typing Source: IPD-IMGT/HLA=11258
Class I
HLA-AA*03:01:01:01,03:01:01:05
HLA-BB*47:01:01:03
HLA-CC*06:02:01:01
Class II
HLA-DPDPA1*01:03:01
DPB1*15:01:01
HLA-DQDQA1*02:01
DQB1*02:02:01
HLA-DRDRA*01:01
DRB1*07:01:01
DRB4*01:01
Disease Adrenal gland hyperplasia III (NCIt: C129302)
Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (ORDO: Orphanet_90794)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=6334310; DOI=10.1073/pnas.81.23.7505
White P.C., New M.I., Dupont B.
HLA-linked congenital adrenal hyperplasia results from a defective gene encoding a cytochrome P-450 specific for steroid 21-hydroxylation.
Proc. Natl. Acad. Sci. U.S.A. 81:7505-7509(1984)

DOI=10.1007/978-1-4612-3552-1_2
Yang S.Y., Milford E.L., Hammerling U., Dupont B.
Description of the reference panel of B-lymphoblastoid cell lines for factors of the HLA system: the B-cell line panel designed for the Tenth International Histocompatibility Workshop.
(In) Immunobiology of HLA. Volume I. Histocompatibility testing 1987; Dupont B. (eds.); pp.11-19; Springer; New York (1989)

DOI=10.1007/978-1-4612-3552-1_4
Mickelson E., Reinsmoen N., Robbins F.-M., Hartzman R.J., Odum N., Svejgaard A., Farrell C., Honeyman M., Flomenberg N., Sell T., Eckels D.
HLA-Dw and HLA-DP typing of the reference panel of B-lymphoblastoid cell lines.
(In) Immunobiology of HLA. Volume I. Histocompatibility testing 1987; Dupont B. (eds.); pp.38-42; Springer; New York (1989)

DOI=10.1007/978-1-4612-3552-1_5
Yang S.Y.
Assignment of HLA-A and HLA-B antigens for the reference panel of B-lymphoblastoid cell lines determined by one-dimensional isoelectric focusing (lD-IEF) gel electrophoresis.
(In) Immunobiology of HLA. Volume I. Histocompatibility testing 1987; Dupont B. (eds.); pp.43-44; Springer; New York (1989)

DOI=10.1007/978-1-4612-3552-1_6
Knowles R.W.
Assignment of HLA-class II alpha and beta chain 2-D gel patterns for the workshop reference panel of B-lymphoblastoid cell lines.
(In) Immunobiology of HLA. Volume I. Histocompatibility testing 1987; Dupont B. (eds.); pp.44-46; Springer; New York (1989)

DOI=10.1007/978-1-4612-3552-1_7
Flomenberg N.
Assignment of T-cell-defined (TCD) HLA class II specificities for the reference panel of B-lymphoblastoid cell lines.
(In) Immunobiology of HLA. Volume I. Histocompatibility testing 1987; Dupont B. (eds.); pp.46-48; Springer; New York (1989)

PubMed=8307784; DOI=10.1016/0198-8859(93)90514-2
Degli-Esposti M.A., Griffiths M.S.J., Daly L.N., Witt C.S., Simons M., Carcassi C., Albert E.D., Giphart M.J., Dawkins R.L.
Characterization of 4AOHW cell line panel including new data for the 10IHW panel.
Hum. Immunol. 38:3-16(1993)

PubMed=8813743; DOI=10.1111/j.1399-0039.1996.tb02596.x
Prasad V.K., Yang S.Y.
Allele assignment for HLA-A, -B, and -C genes to the Tenth International Histocompatibility Workshop cell lines.
Tissue Antigens 47:538-546(1996)

PubMed=25502872; DOI=10.1007/s00251-014-0819-9
Bergseng E., Dorum S., Arntzen M.O., Nielsen M., Nygard S., Buus S., de Souza G.A., Sollid L.M.
Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires.
Immunogenetics 67:73-84(2015)

PubMed=28360230; DOI=10.1101/gr.213538.116
Norman P.J., Norberg S.J., Guethlein L.A., Nemat-Gorgani N., Royce T., Wroblewski E.E., Dunn T., Mann T., Alicata C., Hollenbach J.A., Chang W.-H., Shults Won M., Gunderson K.L., Abi-Rached L., Ronaghi M., Parham P.
Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II.
Genome Res. 27:813-823(2017)

PubMed=29171935; DOI=10.1111/tan.13184
Turner T.R., Hayhurst J.D., Hayward D.R., Bultitude W.P., Barker D.J., Robinson J., Madrigal J.A., Mayor N.P., Marsh S.G.E.
Single molecule real-time DNA sequencing of HLA genes at ultra-high resolution from 126 international HLA and immunogenetics workshop cell lines.
HLA 91:88-101(2018)

PubMed=30844424; DOI=10.1016/j.humimm.2019.03.001
Creary L.E., Guerra S.G., Chong W., Brown C.J., Turner T.R., Robinson J., Bultitude W.P., Mayor N.P., Marsh S.G.E., Saito K., Lam K., Duke J.L., Mosbruger T.L., Ferriola D., Monos D.S., Willis A., Askar M., Fischer G.F., Saw C.L., Ragoussis J., Petrek M., Serra-Pages C., Juan Otero M., Stavropoulos-Giokas C., Dinou A., Ameen R., Al Shemmari S., Spierings E., Gendzekhadze K., Morris G.P., Zhang Q.-H., Kashi Z., Hsu S., Gangavarapu S., Mallempati K.C., Yamamoto F., Osoegawa K., Vayntrub T., Chang C.-J., Hansen J.A., Fernandez-Vina M.A.
Next-generation HLA typing of 382 International Histocompatibility Working Group reference B-lymphoblastoid cell lines: report from the 17th International HLA and Immunogenetics Workshop.
Hum. Immunol. 80:449-460(2019)

Cross-references
Cell line collections (Providers) CLS; 302137
ECACC; 88052047
Cell line databases/resources dbMHC; 49004
IHW; IHW09047
IPD-IMGT/HLA; 11258
Encyclopedic resources Wikidata; Q54947577
Proteomic databases PRIDE; PXD001205
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number21