ID   H1299/LKB1shRNA
AC   CVCL_E7UV
RX   PubMed=18794113;
WW   Provider; Emory OTT; 11191; https://emoryott.technologypublisher.com/techcase/11191
CC   Population: Caucasian.
CC   Karyotypic information: Has lost chromosome Y (from parent cell line).
CC   Knockout cell: Method=shRNA knockdown; HGNC; HGNC:11389; STK11.
CC   Sequence variation: Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C4450; Lung large cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0060 ! NCI-H1299
SX   Male
AG   43Y
CA   Cancer cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
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RX   PubMed=18794113; DOI=10.1158/0008-5472.CAN-08-1484; PMCID=PMC2596073;
RA   Zhong D.-S., Liu X.-J., Khuri F.R., Sun S.-Y., Vertino P.M., Zhou W.;
RT   "LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic
RT   proteins.";
RL   Cancer Res. 68:7270-7277(2008).
//