Cellosaurus iLite IL-23 Assay Ready Cells (CVCL_E7RR)
| Cell line name | iLite IL-23 Assay Ready Cells |
|---|---|
| Synonyms | DT4023L |
| Accession | CVCL_E7RR |
| Resource Identification Initiative | To cite this cell line use: iLite IL-23 Assay Ready Cells (RRID:CVCL_E7RR) |
| Comments | Group: Bird cell line. Characteristics: Genetically engineered and optimized to be responsive to IL23, resulting in the specific expression of firefly luciferase. Normalization of cell counts and serum matrix effects are obtained by a second reporter gene, a Renilla-type luciferase reporter gene construct, under control of a constitutive promoter (Svar Life Science=BM4023). Characteristics: Transfected with the IL23R and IL12RB1 receptor chains both under the control of a CMV reporter, firefly luciferase under the control of STAT5 responsive element and renilla luciferase under the control of a CMV promoter (CelloPub=CLPUB00797). Genetic integration: Method=Transfection; Gene=HGNC; HGNC:5971; IL12RB1. Genetic integration: Method=Transfection; Gene=HGNC; HGNC:19100; IL23R. Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Firefly luciferase. Genetic integration: Method=Transfection; Gene=UniProtKB; P27652; Renilla-type luciferase. Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV). Cell type: B-cell; CL=CL_0000236. |
| Disease | Chicken bursal lymphoma (NCIt: C134556) |
| Species of origin | Gallus gallus (Chicken)
(NCBI Taxonomy: 9031)
Breed/subspecies: Hy-Line SC. |
| Hierarchy | Parent: CVCL_0249 (DT40) |
| Sex of cell | Female |
| Age at sampling | 1D |
| Category | Cancer cell line |
| Web pages | Provider; Svar Life Science; BM4023; https://www.svarlifescience.com/products/bm4023 |
| Publications | CLPUB00797 PubMed=32484379; DOI=10.1177/2472555220923362 |
| Entry history | |
| Entry creation | 10-Apr-2025 |
| Last entry update | 10-Apr-2025 |
| Version number | 1 |