Cellosaurus cell line MDA-MB-231(Cas9) (CVCL

Cellosaurus MDA-MB-231(Cas9) (CVCL_E7JA)

Entry history
Cell line name	MDA-MB-231(Cas9)
Accession	CVCL_E7JA
Resource Identification Initiative	To cite this cell line use: MDA-MB-231(Cas9) (RRID:CVCL_E7JA)
Comments	Group: Triple negative breast cancer (TNBC) cell line. Population: Caucasian. Genetic integration: Method=Transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease	Breast adenocarcinoma (NCIt: C5214)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0062 (MDA-MB-231)
Sex of cell	Female
Age at sampling	51Y
Category	Cancer cell line
Web pages	Provider; BRICS; ECC3037; http://www.brics.ac.cn/cell/template/cell/cell_detail.html?id=3971
Entry creation	10-Apr-2025
Last entry update	10-Apr-2025
Version number	1