| Cell line name |
RKO RCneo-1 |
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| Synonyms |
RCneo-1; RCneo.1 |
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| Accession |
CVCL_E7EW |
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| Resource Identification Initiative |
To cite this cell line use: RKO RCneo-1 (RRID:CVCL_E7EW) |
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| Comments |
Characteristics: Control cell line for RKO HPV-16 protein E6 or E7 transfected cell lines (PubMed=8202487; PubMed=8387205).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Colon carcinoma (NCIt: C4910) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0504 (RKO) |
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| Sex of cell |
Sex unspecified |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| Publications | PubMed=8387205; DOI=10.1073/pnas.90.9.3988; PMCID=PMC46431
Kessis T.D., Slebos R.J.C., Nelson W.G., Kastan M.B., Plunkett B.S., Han S.M., Lorincz A.T., Hedrick Ellenson L., Cho K.R.
Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.
Proc. Natl. Acad. Sci. U.S.A. 90:3988-3992(1993) PubMed=8202487; DOI=10.1073/pnas.91.12.5320; PMCID=PMC43986
Slebos R.J.C., Lee M.H., Plunkett B.S., Kessis T.D., Williams B.O., Jacks T., Hedrick Ellenson L., Kastan M.B., Cho K.R.
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
Proc. Natl. Acad. Sci. U.S.A. 91:5320-5324(1994) |
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| Entry history |
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| Entry creation | 10-Apr-2025 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 1 |
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