ID   VDS-0
AC   CVCL_E7E3
SY   VDS-O; VDSO; VDSO/parental; VDSO/P
RX   PubMed=3018084;
RX   PubMed=9563901;
RX   PubMed=9973220;
CC   Characteristics: Seems to be composed of immature B cells. Does not secretes Ig nor contains intracellular Ig (PubMed=3018084).
CC   Doubling time: 28 hours (PubMed=9563901).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: B-cell; CL=CL_0000236.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_E7E8 ! VDS
CA   Transformed cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
CH   CVCL_E7E4 ! VDSO/CMV-8
CH   CVCL_E7E9 ! VDSO/CMV-9
CH   CVCL_E7E5 ! VDSO/E6-18
CH   CVCL_E7EA ! VDSO/E6-19
//
RX   PubMed=9973220;
RA   Gutierrez, Marina I.
RA   Cherney, Barry W.
RA   Hussain, Azhar
RA   Mostowski, Howard S.
RA   Tosato, Giovanna
RA   Magrath, Ian Trevor
RA   Bhatia, Kishor G.
RT   "Bax is frequently compromised in Burkitt's lymphomas with
RT   irreversible resistance to Fas-induced apoptosis.";
RL   Cancer Res. 59:696-703(1999).
//
RX   PubMed=3018084; DOI=10.4049/jimmunol.137.6.2037;
RA   Tosato, Giovanna
RA   Marti, Gerald E.
RA   Yarchoan, Robert
RA   Heilman, Carole A.
RA   Wang, Frederick
RA   Pike, Sandra Easterly
RA   Korsmeyer, Stanley Joel
RA   Siminovitch, Katherine Anne
RT   "Epstein-Barr virus immortalization of normal cells of B cell lineage
RT   with nonproductive, rearranged immunoglobulin genes.";
RL   J. Immunol. 137:2037-2042(1986).
//
RX   PubMed=9563901;
RA   Fan, Sai-Jun
RA   Cherney, Barry W.
RA   Reinhold, William C.
RA   Rucker, Kimberly
RA   O'Connor, Patrick M.
RT   "Disruption of p53 function in immortalized human cells does not
RT   affect survival or apoptosis after taxol or vincristine treatment.";
RL   Clin. Cancer Res. 4:1047-1054(1998).
//