ID   CRBL
AC   CVCL_E6DZ
DR   ABM; T0759
RX   PubMed=18395703;
CC   Characteristics: Expresses both neuronal and glial cell markers as well as a considerable level of cellular prion protein (PRNP). Susceptible to infections by strain SMB prions (PubMed=18395703).
CC   Doubling time: 15.6 +- 2.5 hours (Note=At 10th passage in 10% FBS), 11.6 hours (Note=At 60th passage in 10% FBS), 10.6 +- 0.7 hours (Note=At 80th passage in 10% FBS), 23.5 hours (Note=At 10th passage in 2.5% FBS) (PubMed=18395703).
CC   Knockout cell: Method=KO mouse; MGI; MGI:98834; Trp53.
CC   Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Brain, cerebellum; UBERON=UBERON_0002037.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   3M
CA   Spontaneously immortalized cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
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RX   PubMed=18395703; DOI=10.1016/j.brainres.2008.02.103; PMCID=PMC2464299;
RA   Mays C.E., Kang H.-E., Kim Y., Shim S.H., Bang J.-E., Woo H.-J.,
RA   Cho Y.-H., Kim J.-B., Ryou C.;
RT   "CRBL cells: establishment, characterization and susceptibility to
RT   prion infection.";
RL   Brain Res. 1208:170-180(2008).
//