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Cellosaurus NCI-H2228-ARY (CVCL_E6DB)

[Text version]
Cell line name NCI-H2228-ARY
Synonyms H2228-ARY
Accession CVCL_E6DB
Resource Identification Initiative To cite this cell line use: NCI-H2228-ARY (RRID:CVCL_E6DB)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_62268; Alectinib (CH5424802; RO5424802; AF-802).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:1316; EML4; Name(s)=EML4-ALK; Note=E6A20 v3 fusion (from parent cell line).
  • Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:9655; PTPN3; Name(s)=ALK-PTPN3 (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln331Ter (c.991C>T); ClinVar=VCV000922893; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1543 (NCI-H2228)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=31900393; DOI=10.1038/s41467-019-13771-5; PMCID=PMC6941996
Tsuji T., Ozasa H., Aoki W., Aburaya S., Yamamoto Funazo T., Furugaki K., Yoshimura Y., Yamazoe M., Ajimizu H., Yasuda Y., Nomizo T., Yoshida H., Sakamori Y., Wake H., Ueda M., Kim Y.H., Hirai T.
YAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation.
Nat. Commun. 11:74.1-74.16(2020)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1