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Cellosaurus iMMEC beclin1+/- BLN2.B8 (CVCL_E6CP)

[Text version]
Cell line name iMMEC beclin1+/- BLN2.B8
Synonyms immortalized Mouse Mammary Epithelial Cell line beclin1+/- H-Bcl-2 BLN2.B8
Accession CVCL_E6CP
Resource Identification Initiative To cite this cell line use: iMMEC beclin1+/- BLN2.B8 (RRID:CVCL_E6CP)
Comments Knockout cell: Method=KO mouse; MGI; MGI:1891828; Becn1 (Note=1 of 2 alleles).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:990; BCL2.
Genetic integration: Method=Transfection; Gene=MGI; MGI:98834; Trp53 (Note=With p.Leu14_Lys302del = p53DD).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03255; Adenovirus 5 E1A protein.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 28285; Adenovirus 5 (Note=E1A).
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Parent: CVCL_E6CJ (iMMEC beclin1+/- BLN2)
Sex of cell Female
Age at sampling 6-8W
Category Transformed cell line
Publications

PubMed=17606641; DOI=10.1101/gad.1565707; PMCID=PMC1899472
Karantza-Wadsworth V., Patel S., Kravchuk O., Chen G.-H., Mathew R., Jin S.-K., White E.
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis.
Genes Dev. 21:1621-1635(2007)

PubMed=18603116; DOI=10.1016/S0076-6879(08)01604-2; PMCID=PMC2857708
Karantza-Wadsworth V., White E.
A mouse mammary epithelial cell model to identify molecular mechanisms regulating breast cancer progression.
Methods Enzymol. 446:61-76(2008)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1