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Cellosaurus oTr1 (CVCL_E5ZD)

[Text version]
Cell line name oTr1
Synonyms oTr-1; Ovine Trophectoderm cell line 1
Accession CVCL_E5ZD
Resource Identification Initiative To cite this cell line use: oTr1 (RRID:CVCL_E5ZD)
Comments Derived from site: In situ; Trophectoderm; UBERON=UBERON_0004345.
Species of origin Ovis aries (Sheep) (NCBI Taxonomy: 9940)
Sex of cell Sex unspecified
Age at sampling 15FD
Category Spontaneously immortalized cell line
Publications

PubMed=18339715; DOI=10.1210/en.2007-1367
Kim J.-Y., Song G., Gao H.-J., Farmer J.L., Satterfield M.C., Burghardt R.C., Wu G., Johnson G.A., Spencer T.E., Bazer F.W.
Insulin-like growth factor II activates phosphatidylinositol 3-kinase-protooncogenic protein kinase 1 and mitogen-activated protein kinase cell signaling pathways, and stimulates migration of ovine trophectoderm cells.
Endocrinology 149:3085-3094(2008)

PubMed=20385232; DOI=10.1016/j.matbio.2010.04.001
Kim J.-Y., Erikson D.W., Burghardt R.C., Spencer T.E., Wu G.-Y., Bayless K.J., Johnson G.A., Bazer F.W.
Secreted phosphoprotein 1 binds integrins to initiate multiple cell signaling pathways, including FRAP1/mTOR, to support attachment and force-generated migration of trophectoderm cells.
Matrix Biol. 29:369-382(2010)

PubMed=20844281; DOI=10.1095/biolreprod.110.085753
Kim J.-Y., Burghardt R.C., Wu G.-Y., Johnson G.A., Spencer T.E., Bazer F.W.
Select nutrients in the ovine uterine lumen. VIII. Arginine stimulates proliferation of ovine trophectoderm cells through MTOR-RPS6K-RPS6 signaling cascade and synthesis of nitric oxide and polyamines.
Biol. Reprod. 84:70-78(2011)

PubMed=27512152; DOI=10.1095/biolreprod.115.137943
Wang X.-Q., Johnson G.A., Burghardt R.C., Wu G.-Y., Bazer F.W.
Uterine histotroph and conceptus development. II. Arginine and secreted phosphoprotein 1 cooperatively stimulate migration and adhesion of ovine trophectoderm cells via focal adhesion-MTORC2 mediated cytoskeleton reorganization.
Biol. Reprod. 95:71.1-71.12(2016)

Cross-references
Cell line collections (Providers) ABM; T0435
Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1