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Cellosaurus SF295 MX500 (CVCL_E5TA)

[Text version]
Cell line name SF295 MX500
Accession CVCL_E5TA
Resource Identification Initiative To cite this cell line use: SF295 MX500 (RRID:CVCL_E5TA)
Comments Population: Caucasian.
Characteristics: Resistant to 500 nM of mitoxantrone (PubMed=15993268).
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Derived from site: In situ; Brain, left temporal lobe; UBERON=UBERON_0002808.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1690 (SF295)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=15993268; DOI=10.1016/j.cancergencyto.2004.12.013
Rao V.K., Wangsa Zong D., Robey R.W., Huff L.M., Honjo Y., Hung J., Knutsen T., Ried T., Bates S.E.
Characterization of ABCG2 gene amplification manifesting as extrachromosomal DNA in mitoxantrone-selected SF295 human glioblastoma cells.
Cancer Genet. Cytogenet. 160:126-133(2005)

Cross-references
Cell line collections (Providers) ABM; T8041
Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1