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Cellosaurus ZR-75-1 BCAR4 clone 2B (CVCL_E4WW)

[Text version]
Cell line name ZR-75-1 BCAR4 clone 2B
Synonyms ZR-BCAR4 2B
Accession CVCL_E4WW
Resource Identification Initiative To cite this cell line use: ZR-75-1 BCAR4 clone 2B (RRID:CVCL_E4WW)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:22170; BCAR4.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=16778085; DOI=10.1158/1541-7786.MCR-05-0156
Meijer D., van Agthoven T., Bosma P.T., Nooter K., Dorssers L.C.J.
Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells.
Mol. Cancer Res. 4:379-386(2006)

Cross-references
Cell line collections (Providers) CancerTools; 154626
Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1