ID   ZR-75-1 BCAR4 clone 2A
AC   CVCL_E4WV
SY   ZR-BCAR4 2A
DR   CancerTools; 154625
RX   PubMed=16778085;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
CC   Sequence variation: Mutation; HGNC; 5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:22170; BCAR4.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0588 ! ZR-75-1
SX   Female
AG   63Y
CA   Cancer cell line
DT   Created: 19-12-24; Last updated: 19-12-24; Version: 1
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RX   PubMed=16778085; DOI=10.1158/1541-7786.MCR-05-0156;
RA   Meijer D., van Agthoven T., Bosma P.T., Nooter K., Dorssers L.C.J.;
RT   "Functional screen for genes responsible for tamoxifen resistance in
RT   human breast cancer cells.";
RL   Mol. Cancer Res. 4:379-386(2006).
//