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Cellosaurus ZR-75-1 AKT1 pool B (CVCL_E4WR)

[Text version]
Cell line name ZR-75-1 AKT1 pool B
Synonyms ZR-AKT1 pool B
Accession CVCL_E4WR
Resource Identification Initiative To cite this cell line use: ZR-75-1 AKT1 pool B (RRID:CVCL_E4WR)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:391; AKT1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=18351453; DOI=10.1007/s10549-008-9969-5
van Agthoven T., Veldscholte J.W., Smid M., van Agthoven T.L.A., Vreede L., Broertjes M., de Vries I., de Jong D., Sarwari R., Dorssers L.C.J.
Functional identification of genes causing estrogen independence of human breast cancer cells.
Breast Cancer Res. Treat. 114:23-30(2009)

Cross-references
Cell line collections (Providers) CancerTools; 154623
Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1