| Cell line name |
Bx-GEM200 |
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| Synonyms |
BxPc-3-GEM |
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| Accession |
CVCL_E4NH |
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| Resource Identification Initiative |
To cite this cell line use: Bx-GEM200 (RRID:CVCL_E4NH) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_175901; Gemcitabine (Gemzar).
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val487_Pro492delinsAla (c.1460_1474delGTGTAGGTGCTGTCA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; None_reported; -; Zygosity=- (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Pancreatic ductal adenocarcinoma (NCIt: C9120) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_E4NG (Bx-GEM100) |
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| Sex of cell |
Female |
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| Age at sampling |
61Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=26828016; DOI=10.1016/j.canlet.2016.01.038
Fan P., Liu L., Yin Y.-F., Zhao Z.-F., Zhang Y.-Y., Amponsah P.S., Xiao X., Bauer N., Abukiwan A., Nwaeburu C.C., Gladkich J., Gao C., Schemmer P., Gross W., Herr I.
MicroRNA-101-3p reverses gemcitabine resistance by inhibition of ribonucleotide reductase M1 in pancreatic cancer.
Cancer Lett. 373:130-137(2016) |
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| Entry history |
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| Entry creation | 19-Dec-2024 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 1 |
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