Cellosaurus cell line BxPC-3 XL-4 (CVCL

Cellosaurus BxPC-3 XL-4 (CVCL_E4NB)

[Text version]

Cell line name

BxPC-3 XL-4

Synonyms

XL-4

Accession

CVCL_E4NB

Resource Identification Initiative

To cite this cell line use: BxPC-3 XL-4 (RRID:CVCL_E4NB)

Comments

Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_72317; Carbozantinib (Cometriq).
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.

Sequence variations

Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val487_Pro492delinsAla (c.1460_1474delGTGTAGGTGCTGTCA); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:6407; KRAS; None_reported; -; Zygosity=- (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).

Disease

Pancreatic ductal adenocarcinoma (NCIt: C9120)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_E4NA (BxPC-3 XL-3)
Children:

CVCL_E4NC (BxPC-3 XL-5)

Sex of cell

Female

Age at sampling

61Y