ID   ZR-75-1 XIV-51
AC   CVCL_E4MY
SY   ZR-75-1 [XIV-51]
DR   CancerTools; 154615
RX   PubMed=8413311;
RX   PubMed=18351453;
CC   Population: Caucasian.
CC   Characteristics: Infected with an amphotropic defective murine retrovirus. Retroviral insertion was used in order to identify genes responsible for estrogen-independence and thus tamoxifen resistant (PubMed=8413311; PubMed=18351453).
CC   Characteristics: Genes likely to be responsible to resistance in this cell line are NCOR2 and SPINK4 (PubMed=18351453).
CC   Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
CC   Sequence variation: Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0588 ! ZR-75-1
SX   Female
AG   63Y
CA   Cancer cell line
DT   Created: 19-12-24; Last updated: 14-08-25; Version: 3
//
RX   PubMed=18351453; DOI=10.1007/s10549-008-9969-5;
RA   van Agthoven, Ton
RA   Veldscholte, Jos Willibrordus
RA   Smid, Marcel
RA   van Agthoven, Thecla L.A.
RA   Vreede, Lilian
RA   Broertjes, Marieke
RA   de Vries, Ingrid
RA   de Jong, Danielle
RA   Sarwari, Roya
RA   Dorssers, Lambert C.J.
RT   "Functional identification of genes causing estrogen independence of
RT   human breast cancer cells.";
RL   Breast Cancer Res. Treat. 114:23-30(2009).
//
RX   PubMed=8413311; DOI=10.1210/mend.7.7.8413311;
RA   Dorssers, Lambert C.J.
RA   van Agthoven, Ton
RA   Dekker, Anita
RA   van Agthoven, Thecla L.A.
RA   Kok, Elisabeth M.
RT   "Induction of antiestrogen resistance in human breast cancer cells by
RT   random insertional mutagenesis using defective retroviruses:
RT   identification of bcar-1, a common integration site.";
RL   Mol. Endocrinol. 7:870-878(1993).
//