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Cellosaurus ZR-75-1 XIV-10 (CVCL_E4MG)

[Text version]
Cell line name ZR-75-1 XIV-10
Synonyms ZR-75-1 [XIV-10]
Accession CVCL_E4MG
Resource Identification Initiative To cite this cell line use: ZR-75-1 XIV-10 (RRID:CVCL_E4MG)
Comments Population: Caucasian.
Characteristics: Infected with an amphotropic defective murine retrovirus. Retroviral insertion was used in order to identify genes responsible for estrogen-independence and thus tamoxifen resistant (PubMed=8413311; PubMed=18351453).
Characteristics: Gene likely to be responsible to resistance in this cell line is CFTR (PubMed=18351453).
Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=8413311; DOI=10.1210/mend.7.7.8413311
Dorssers L.C.J., van Agthoven T., Dekker A., van Agthoven T.L.A., Kok E.M.
Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site.
Mol. Endocrinol. 7:870-878(1993)

PubMed=18351453; DOI=10.1007/s10549-008-9969-5
van Agthoven T., Veldscholte J.W., Smid M., van Agthoven T.L.A., Vreede L., Broertjes M., de Vries I., de Jong D., Sarwari R., Dorssers L.C.J.
Functional identification of genes causing estrogen independence of human breast cancer cells.
Breast Cancer Res. Treat. 114:23-30(2009)

Cross-references
Cell line collections (Providers) CancerTools; 154599
Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1