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Cellosaurus A431 GR (CVCL_E4DP)

[Text version]
Cell line name A431 GR
Synonyms A431-GR; A431_GR
Accession CVCL_E4DP
Resource Identification Initiative To cite this cell line use: A431 GR (RRID:CVCL_E4DP)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Sequence variations
  • Gene fusion; HGNC; HGNC:3236; EGFR + HGNC; HGNC:9237; PPARGC1A; Name(s)=EGFR-PPARGC1A (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease Skin squamous cell carcinoma (NCIt: C4819)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0037 (A-431)
Sex of cell Female
Age at sampling 85Y
Category Cancer cell line
Publications

PubMed=18568074; DOI=10.1172/JCI34588; PMCID=PMC2430495
Guix M., Faber A.C., Wang S.-Z.E., Olivares M.G., Song Y., Qu S., Rinehart C., Seidel B., Yee D., Arteaga C.L., Engelman J.A.
Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins.
J. Clin. Invest. 118:2609-2619(2008)

Cross-references
Gene expression databases GEO; GSM270527
GEO; GSM270528
GEO; GSM270529
Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1