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Cellosaurus HCC827 BIR (CVCL_E4DK)

[Text version]
Cell line name HCC827 BIR
Synonyms HCC827BIR
Accession CVCL_E4DK
Resource Identification Initiative To cite this cell line use: HCC827 BIR (RRID:CVCL_E4DK)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_232716; (20R)-10,15,20-trimethyl-2-[(4-methylpiperazin-1-yl)methyl]-18,19,20,21-tetrahydro-15H,17H-12,8-(metheno)pyrazolo[3',4':2,3][1,5,10,12]oxatriazacycloheptadecino[12,11-a]benzimidazol-7(6H)-one (BI-4020).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=39061985; DOI=10.3390/biomedicines12071412; PMCID=PMC11273927
Fukuda S., Suda K., Hamada A., Oiki H., Ohara S., Ito M., Soh J., Mitsudomi T., Tsutani Y.
Potential utility of a 4th-generation EGFR-TKI and exploration of resistance mechanisms -- an in vitro study.
Biomedicines 12:1412.1-1412.13(2024)

Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1