ID   PC9/3-2
AC   CVCL_E4DF
RX   PubMed=28422737;
CC   Population: Chinese; Han and Japanese.
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple_edited; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous; Note=By CRISPR/Cas9 (PubMed=28422737).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_B260 ! PC-9
SX   Male
AG   45Y
CA   Cancer cell line
DT   Created: 19-12-24; Last updated: 19-12-24; Version: 1
//
RX   PubMed=28422737; DOI=10.18632/oncotarget.16752; PMCID=PMC5482658;
RA   Park M.-Y., Jung M.H., Eo E.Y., Kim S., Lee S.H., Lee Y.J., Park J.S.,
RA   Cho Y.J., Chung J.H., Kim C.H., Yoon H.I., Lee J.H., Lee C.-T.;
RT   "Generation of lung cancer cell lines harboring EGFR T790M mutation by
RT   CRISPR/Cas9-mediated genome editing.";
RL   Oncotarget 8:36331-36338(2017).
//