ID   BJ SiPS-D TH-TdTomato ATP10B KO clone #1
AC   CVCL_E3SX
SY   TH-TdTomato BJ SiPS ATP10B KO clone #1
RX   DOI=10.1101/2024.07.09.602700;
CC   Population: Caucasian.
CC   Characteristics: Fluorescent (tdTomato) reporter cell line for TH expression. Using CRISPR/Cas9 a P2A-tdTomato construct was introduced in the C-terminal end of TH (from parent cell line).
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:13543; ATP10B.
CC   Genetic integration: Method=CRISPR/Cas9; Gene=FPbase; PGG5S; tdTomato (Note=Bright red fluorescent protein derived from drFP583 (DsRed)).
CC   Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.
CC   Cell type: Fibroblast of foreskin; CL=CL_1001608.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C8FN ! BJ SiPS-D TH-TdTomato
SX   Male
AG   <1M
CA   Induced pluripotent stem cell
DT   Created: 19-12-24; Last updated: 19-12-24; Version: 1
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RX   DOI=10.1101/2024.07.09.602700;
RA   Sanchiz-Calvo M., Coccia E., Cawthorne C., Parfitt G.M., Van Laere K.,
RA   Torre-Muruzabal T., Cabezudo D., Tsafaras G., Cascalho A.C.C.,
RA   Van den Haute C., Vangheluwe P., Blanchard J., Bentea E., Baekelandt V.;
RT   "Loss of the lysosomal lipid flippase ATP10B leads to progressive
RT   dopaminergic neurodegeneration and Parkinsonian motor deficits.";
RL   bioRxiv 2024:07.09.602700-07.09.602700(2024).
//