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Cellosaurus HS5-CD40L-IL4-IL21 (CVCL_E3RK)

[Text version]
Cell line name HS5-CD40L-IL4-IL21
Accession CVCL_E3RK
Resource Identification Initiative To cite this cell line use: HS5-CD40L-IL4-IL21 (RRID:CVCL_E3RK)
Comments Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11935; CD40LG.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:6005; IL21.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:6014; IL4.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88346; Cd8a.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Bone marrow, stroma; UBERON=UBERON_0007195.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E3RI (HS5-CD40L-IL4)
Sex of cell Male
Age at sampling 30Y
Category Transformed cell line
Publications

PubMed=38877102; DOI=10.1038/s41375-024-02284-w; PMCID=PMC11286525
Hoferkova E., Seda V., Kadakova S., Verner J., Loja T., Matulova K., Skuhrova Francova H., Ondrouskova E., Filip D., Blavet N., Boudny M., Mladonicka Pavlasova G., Vecera J., Ondrisova L., Pavelkova P., Hlavac K., Kostalova L., Michaelou A., Pospisilova S., Dorazilova J., Chochola V., Jaros J., Doubek M., Jarosova M., Hampl A., Vojtova L., Kren L., Mayer J., Mraz M.
Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs.
Leukemia 38:1699-1711(2024)

Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1