ID   HS5-CD40L(LOW)-IL4
AC   CVCL_E3RJ
SY   HS5-CD40LLOW-IL4
RX   PubMed=38877102;
CC   Population: Caucasian.
CC   Characteristics: Expresses low level of CD40LG (PubMed=38877102).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11935; CD40LG.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:6014; IL4.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Derived from site: In situ; Bone marrow, stroma; UBERON=UBERON_0007195.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_E3RG ! HS5-IL4
SX   Male
AG   30Y
CA   Transformed cell line
DT   Created: 19-12-24; Last updated: 19-12-24; Version: 1
//
RX   PubMed=38877102; DOI=10.1038/s41375-024-02284-w; PMCID=PMC11286525;
RA   Hoferkova E., Seda V., Kadakova S., Verner J., Loja T., Matulova K.,
RA   Skuhrova Francova H., Ondrouskova E., Filip D., Blavet N., Boudny M.,
RA   Mladonicka Pavlasova G., Vecera J., Ondrisova L., Pavelkova P.,
RA   Hlavac K., Kostalova L., Michaelou A., Pospisilova S., Dorazilova J.,
RA   Chochola V., Jaros J., Doubek M., Jarosova M., Hampl A., Vojtova L.,
RA   Kren L., Mayer J., Mraz M.;
RT   "Stromal cells engineered to express T cell factors induce robust CLL
RT   cell proliferation in vitro and in PDX co-transplantations allowing
RT   the identification of RAF inhibitors as anti-proliferative drugs.";
RL   Leukemia 38:1699-1711(2024).
//