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Cellosaurus Ba/F3 EGFR-L718Q/T790M/L858R (CVCL_E3ME)

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Cell line name Ba/F3 EGFR-L718Q/T790M/L858R
Synonyms Ba/F3 EGFR-L858R/T790M/L718Q
Accession CVCL_E3ME
Resource Identification Initiative To cite this cell line use: Ba/F3 EGFR-L718Q/T790M/L858R (RRID:CVCL_E3ME)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3236; EGFR (Note=With p.Leu718Gln (c.2153T>A), p.Thr790Met (c.2369C>T) and p.Leu858Arg (c.2573T>G)).
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Caution: The parent cell line was originally thought to originate from a BALB/c mouse but is in fact from a C3H mouse.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Pro-B cell; CL=CL_0000826.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C3H.
Hierarchy Parent: CVCL_0161 (Ba/F3)
Category Transformed cell line
Publications

PubMed=34526717; DOI=10.1038/s41586-021-03898-1; PMCID=PMC8481125
Robichaux J.P., Le X.-N., Vijayan R.S.K., Hicks J.K., Heeke S., Elamin Y.Y., Lin H.Y., Udagawa H., Skoulidis F., Tran H., Varghese S., He J.-Q., Zhang F.-H., Nilsson M.B., Hu L.-M., Poteete A., Rinsurongkawong W., Zhang X.-S., Ren C.-H., Liu X.-K., Hong L.-Z., Zhang J.-J., Diao L.-X., Madison R.W., Schrock A.B., Saam J., Raymond V.M., Fang B.-L., Wang J., Ha M.J., Cross J.B., Gray J.E., Heymach J.V.
Structure-based classification predicts drug response in EGFR-mutant NSCLC.
Nature 597:732-737(2021)

Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1