ID   CHO-K1 MUC1-IgG
AC   CVCL_E3IX
SY   CHO MUC1
RX   PubMed=12950230;
RX   PubMed=16319059;
CC   Characteristics: The transfected MUC1 construct contains the first 16 tandem repeats of the extracellular domain of MUC1 followed by an enterokinase cleavage site (DDDDK) fusef to exon 1-3 of mouse IgG2a Fc (PubMed=16319059).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:7508; MUC1 (Note=With p.Ala381_Leu1255del).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_0214 ! CHO-K1
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 19-12-24; Last updated: 19-12-24; Version: 1
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RX   PubMed=12950230; DOI=10.1042/bj20031130; PMCID=PMC1223800;
RA   Backstrom M., Link T., Olson F.J., Karlsson H., Graham R.A., Picco G.,
RA   Burchell J.M., Taylor-Papadimitriou J., Noll T., Hansson G.C.;
RT   "Recombinant MUC1 mucin with a breast cancer-like O-glycosylation
RT   produced in large amounts in Chinese-hamster ovary cells.";
RL   Biochem. J. 376:677-686(2003).
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RX   PubMed=16319059; DOI=10.1074/jbc.M511826200;
RA   Sewell R., Backstrom M., Dalziel M., Gschmeissner S., Karlsson H.,
RA   Noll T., Gatgens J., Clausen H., Hansson G.C., Burchell J.M.,
RA   Taylor-Papadimitriou J.;
RT   "The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and
RT   is responsible for the synthesis of the tumor-associated sialyl-Tn
RT   O-glycan in human breast cancer.";
RL   J. Biol. Chem. 281:3586-3594(2006).
//