ID   HCI-EC-23
AC   CVCL_E3GB
SY   Huntsman Cancer Institute-Endometrial cancer-23
DR   GEO; GSM6421755
DR   GEO; GSM6421756
DR   GEO; GSM6421757
DR   GEO; GSM6421761
DR   GEO; GSM6421762
DR   GEO; GSM6421763
DR   GEO; GSM6421764
DR   GEO; GSM6421765
DR   GEO; GSM6421766
DR   GEO; GSM6421767
DR   GEO; GSM6421768
DR   GEO; GSM6727284
DR   GEO; GSM6727285
DR   Millipore; SCC641
RX   PubMed=36396974;
CC   Characteristics: Retains ER expression and hormonal responsiveness (PubMed=36396974).
CC   Characteristics: Established from a mouse xenograft (EC-PDX-23) (PubMed=36396974).
CC   Doubling time: ~30 hours (PubMed=36396974).
CC   Microsatellite instability: Instable (MSI-high) (PubMed=36396974).
CC   Sequence variation: Mutation; HGNC; HGNC:11110; ARID1A; Simple; p.Gly801Valfs*32 (c.2402delG); Zygosity=Unspecified (PubMed=36396974).
CC   Sequence variation: Mutation; HGNC; HGNC:11110; ARID1A; Simple; p.Gln2070Ter (c.6208C>T); Zygosity=Unspecified (PubMed=36396974).
CC   Sequence variation: Mutation; HGNC; HGNC:15840; KMT2B; Simple; p.Gly1733Trpfs*6 (c.5196dupT); Zygosity=Unspecified (PubMed=36396974).
CC   Sequence variation: Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Ser4327Glnfs*7 (c.12978dupG); Zygosity=Unspecified (PubMed=36396974).
CC   Sequence variation: Mutation; HGNC; HGNC:14234; NSD1; Simple; p.Met1531Cysfs*43 (c.4591delA); Zygosity=Unspecified (PubMed=36396974).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu39Lys (c.115G>A); ClinVar=VCV003258061; Zygosity=Unspecified (PubMed=36396974).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Arg93Gln (c.278G>A); ClinVar=VCV000419128; Zygosity=Unspecified (PubMed=36396974).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg130Gly (c.388C>G); ClinVar=VCV000375958; Zygosity=Unspecified (PubMed=36396974).
CC   Sequence variation: Mutation; HGNC; HGNC:777; ZFHX3; Simple; p.Arg2693Ter (c.8077C>T); Zygosity=Unspecified (PubMed=36396974).
CC   Omics: H3K27ac ChIP-seq epigenome analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
ST   Source(s): Millipore=SCC641
ST   Amelogenin: X
ST   CSF1PO: 12,13
ST   D13S317: 11,12
ST   D16S539: 11,12
ST   D18S51: 12,15
ST   D21S11: 28,29
ST   D3S1358: 16,17
ST   D5S818: 11
ST   D7S820: 10,11
ST   D8S1179: 12,13,14
ST   FGA: 20,24,25
ST   Penta D: 11,12
ST   Penta E: 12,15
ST   TH01: 9.3,10
ST   TPOX: 8,9
ST   vWA: 17,19,20
DI   NCIt; C40145; Type I endometrial adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   66Y
CA   Cancer cell line
DT   Created: 19-12-24; Last updated: 19-12-24; Version: 1
//
RX   PubMed=36396974; DOI=10.1038/s41598-022-24211-8; PMCID=PMC9672046;
RA   Rush C.M., Blanchard Z., Polaski J.T., Osborne K.S., Osby K.,
RA   Vahrenkamp J.M., Yang C.-H., Lum D.H., Hagan C.R., Leslie K.K.,
RA   Pufall M.A., Thiel K.W., Gertz J.;
RT   "Characterization of HCI-EC-23 a novel estrogen- and
RT   progesterone-responsive endometrial cancer cell line.";
RL   Sci. Rep. 12:19731-19731(2022).
//