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Cellosaurus SK-OV-3/pVgRXR/pINDp53wt (CVCL_E3EA)

[Text version]
Cell line name SK-OV-3/pVgRXR/pINDp53wt
Accession CVCL_E3EA
Resource Identification Initiative To cite this cell line use: SK-OV-3/pVgRXR/pINDp53wt (RRID:CVCL_E3EA)
Comments Population: Caucasian.
Characteristics: Transfected with the pVgRXR vector that contains the VgEcR fusion protein under the control of a CMV promoter and RXRA under the control of a RSV promoter as well as BleoR. Also transfected with pINDp53wt (PubMed=15755800).
Genetic integration: Method=Transfection; Gene=FlyBase_Gene; FBgn0000546; EcR (Note=With p.Met1_Val221del, as 2nd part of VgECR).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:10477; RXRA.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11998; TP53.
Genetic integration: Method=Transfection; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Thr412del, as 1st part of VgECR).
Genetic integration: Method=Transfection; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E3E8 (SK-OV-3/pVgRXR)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Publications

PubMed=15755800; DOI=10.1093/mutage/gei016
Oliva-Trastoy M., Defais M., Larminat F.
Resistance to the antibiotic zeocin by stable expression of the Sh ble gene does not fully suppress zeocin-induced DNA cleavage in human cells.
Mutagenesis 20:111-114(2005)

Entry history
Entry creation10-Sep-2024
Last entry update10-Apr-2025
Version number3