ID   SK-OV-3/pVgRXR
AC   CVCL_E3E8
SY   SK-OV-3 Zeo(R); SK-OV-3 ZeoR
RX   PubMed=15755800;
CC   Population: Caucasian.
CC   Characteristics: Transfected with the pVgRXR vector that contains the VgEcR fusion protein under the control of a CMV promoter and RXRA under the control of a RSV promoter as well as BleoR (PubMed=15755800).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; 10477; RXRA.
CC   Genetic integration: Method=Transfection; Gene=FlyBase_Gene; FBgn0000546; EcR (Note=With p.Met1_Val221del, as 2nd part of VgECR).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Thr412del, as 1st part of VgECR).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C7978; Ovarian serous cystadenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0532 ! SK-OV-3
SX   Female
AG   64Y
CA   Cancer cell line
DT   Created: 10-09-24; Last updated: 10-09-24; Version: 1
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RX   PubMed=15755800; DOI=10.1093/mutage/gei016;
RA   Oliva-Trastoy M., Defais M., Larminat F.;
RT   "Resistance to the antibiotic zeocin by stable expression of the Sh
RT   ble gene does not fully suppress zeocin-induced DNA cleavage in human
RT   cells.";
RL   Mutagenesis 20:111-114(2005).
//