ID   KGN-MXIV
AC   CVCL_E3DH
RX   PubMed=24389730;
CC   Population: Japanese.
CC   Characteristics: Control cell line for KGN-YAP (Cellosaurus=CVCL_E3DI) and KGN-YAP(S127A) (Cellosaurus=CVCL_E3DJ). Transduced with an empty vector (PubMed=24389730).
CC   Sequence variation: Mutation; HGNC; HGNC:1092; FOXL2; Simple; p.Cys134Trp (c.402C>G); ClinVar=VCV000376348; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:16262; YAP1 (Note=With p.Ser127Ala).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:16262; YAP1.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170.
DI   NCIt; C6261; Ovarian granulosa cell tumor
DI   ORDO; Orphanet_99915; Maligant granulosa cell tumor of the ovary
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0375 ! KGN
SX   Female
AG   63Y
CA   Cancer cell line
DT   Created: 10-09-24; Last updated: 14-08-25; Version: 4
//
RX   PubMed=24389730; DOI=10.1530/ERC-13-0339; PMCID=PMC4222524;
RA   Fu, David
RA   Lv, Xiang-Min
RA   Hua, Guo-Hua
RA   He, Chun-Bo
RA   Dong, Ji-Xin
RA   Lele, Subodh Mukund
RA   Li, David Wan-Cheng
RA   Zhai, Qiong-Li
RA   Davis, John S.
RA   Wang, Cheng
RT   "YAP regulates cell proliferation, migration, and steroidogenesis in
RT   adult granulosa cell tumors.";
RL   Endocr. Relat. Cancer 21:297-310(2014).
//